After originating the role with the Brian De Palma-helmed 1976 adaptation, Sissy Spacek’s breakout performance in the first Carrie became synonymous with the role.

In 2002, Angela Bettis took on the character in NBC’s TV movie adaptation, before Chloë Grace Moretz updated the character for the digital age in Sony’s 2013 big-screen take from director Kimberly Peirce.

With Mike Flanagan taking over the source material for the Prime Video series, Summer H. Howell (Curse of Chucky, Cult of Chucky) was cast as Carrie last August, bringing a refreshing sense of optimism to the role as the series fleshes out the ’74 book and introduces elements familiar to today’s youth.

Following Piper Laurie’s iconically chilling performance as matriarch Margaret White in the 1976 original, Patricia Clarkson took on the role for the 2002 TV movie, with Julianne Moore giving her portrayal in the 2017 movie.

In the latest adaptation, Samantha Sloyan (Midnight Mass, The Life of Chuck) teams up with frequent collaborator Mike Flanagan to bring a more maternal touch to the role, which has long been played with a cold harshness.

Starring as reformed mean girl Sue Snell in the original movie was Amy Irving, before Kandyse McClure took on the character in 2002, followed by Gabriella Wilde in 2017.

In Prime’s Carrie, Siena Agudong (F9, Netflix’s Resident Evil) plays Carrie’s new friend, whose realtor mom pushes her to hang out with the new girl after she and her mother are found locked in a closet following her father’s death.

In 1976, Nancy Allen originated the role of Carrie’s bully Chris Hargensen in perfect ’70s mean girl fashion, with Emilie de Ravin and Portia Doubleday bringing their own brands of cruelty to the role in subsequent versions.

While Mike Flanagan’s Carrie doesn’t paint Chris as any less of a mean girl, Alison Thornton (School Spirits, Elle) plays her with the added depth allowed by the show’s eight-episode run, diving more into her troubled home life.

Originated by the great Betty Buckley in 1976, Miss Desjardins has always been Carrie’s strongest ally, played by Rena Sofer in 2002 and Judy Greer in 2013.

In Prime Video’s Carrie, Mike Flanagan proves that teachers have a life outside of school, giving Amber Midthunder’s Rita Desjardin a rich personal life that heads for its own tailspin as she attempts to get through to Carrie before something bad happens.

Way back when ruffled tuxedo shirts were in style, William Katt was the first to play Sue’s kindhearted boyfriend Tommy Ross.

Following Tobias Mehler and Ansel Elgort’s portrayal of the prom king back in 2002 and 2013, Joel Oulette is taking on the character in Mike Flanagan’s series.

Two years before he was singing “Greased Lightnin'”, John Travolta had another memorable onscreen auto moment in the 1976 adaptation of Carrie, playing Chris’ deranged boyfriend Billy Nolan.

After Jesse Cadotte and Alex Russell played the delinquent in 2002 and 2013, Mike Flanagan sheds some more light on the character’s relationship with Chris, casting Arthur Conti as Billy.