To the Editor In their recent article in JAMA Oncology, Muth et al reported that mean Edmonton Symptom Assessment System-revised (ESAS-r) burden scores rose significantly across the year before medical assistance in dying in 34 adolescent and young adult patients with cancer, and proposed a month 5 patient-reported symptom trigger for specialist palliative care referral. The authors acknowledged ESAS-r missingness and the modest cohort size. However, 2 features of their analysis—neither raised in the Discussion—undermine this trigger.